[1] STONE, WL, BASIT, H., ZUBAIR, M., BURNS, B., *Pathology, Inflammation*, StatPearls online (2025). IMMUNE RESPONSE IN CHRONIC INFLAMMATION

[2] TURCOTTE, C., BLANCHET, MR, LAVIOLETTE, M., FLAMAND, N., *The CB2 receptor and its role as a regulator of inflammation*, Cellular and Molecular Life Sciences, vol. 73, no. 23 (2016), pp. 4449–4470. REGULATION OF INFLAMMATION IN LEUKOCYTES VIA THE CB2 RECEPTOR

[3] ATWOOD, B., K., STRAIKER, A., MACKIE, K., *CB2: Therapeutic target-in-waiting*, Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 38, no. 1 (2012), pp. 16–20. CB2 RECEPTOR: A TARGET FOR THE TREATMENT OF INFLAMMATION AND BONE DISEASES

Four patented, clinically tested extracts.

Palmitoylethanolamide has been investigated by scientists in more than 350 studies, and our formulation is the subject of 8 different clinical studies (on Covid relief and long Covid[1], on pain reduction[2], on knee arthritis support[3], on faster recovery after sport[4], on reducing pain during the menstrual cycle[5], etc.).

Beta caryophyne is the subject of a clinical study on pain reduction comparable to analgesics such as ibuprofen and paracetamol.[6]

Eugenol is a powerful antioxidant that scavenges free radicals in cells. It reduces most markers of inflammation through the NF- channelκB.[7]

Curcumin C3 complex is one of the most clinically tested turmeric extracts in the world with over 50 studies.[8]

[1] FONNESU, R., Palmitoylethanolamide (PEA) Inhibits SARS-CoV-2 Entry by Interacting with S Protein and ACE-2 Receptor, Viruses, Vol. 14 (2022), pp. 1080-1898.

[2] BRISKEY, D., EBELT, P., STEELS, E., SUBAH, S., BOGODA, N., RAO., A., Efficacy of Palmitoylethanolamide (Levagen+TM) Compared to Ibuprofen for Reducing Headache Pain Severity and Duration in Healthy Adults: A Double-Blind, Parallel, Randomized Clinical Trial, 690 Food and Nutrition Sciences, Vol. 13 (2022), pp. 690-701.

[3] BRISKEY, D., ROCHE, G., RAO, A., The Effect of a Dispersible Palmitoylethanolamide (Levagen+) Compared to a Placebo for Reducing Joint Pain in an Adult Population - A Randomised, Double-Blind Study, International Journal of Nutrition and Food Sciences, Vol. 10, No. 1 (2021), pp. 9-13.

[4] MALLARD, A., BRISKEY, D.,RICHARDS, A., MILLS, D., RAO, A., The effect of orally dosed Levagen+ (palmitoylethanolamide) on exercise recovery in healthy males - a double blind, randomized, placebo-controlled study, Nutrients, Vol. 12, No. 3 (2020), p. 596.

[5] RAO, A., ERICKSON, J., BRISKEY, D., Palmitoylethanolamide (Levagen+) for acute menstrual pain: a randomized, crossover, doubleblind, placebo-controlled trial, Women & Health, Vol. 65, No. 3 (2025), pp. 237-245.

[6] BIOSFERED, PipeNig®, a black pepper (Piper nigrum) extract with standardized content of (E)-β-caryophyllene, A natural source of an endo-cannabinoid CB2 receptor agonist, Nutrafoods, Vol. 17 (2018), pp. N12-N23.

[7] BARBOZA, J. N., DA SILVA MAIA BEZERRA FILHO, C., SILVA, R.O., MEDEIROS, J.V.R., DE SOUSA, D.P., An Overview on the Anti-inflammatory Potential and Antioxidant Profile of Eugenol, Oxidative Medicine and Cellular Longevity, Vol. 2018, pp. 3957262.

[8] SABINSA, Curcumin C3 Commplex, available at: https://sabinsa.eu/products-from-sabinsa/127-curcumin-c3-complex.