Three natural extracts.

Palmitoylethanolamide in palm extract, beta caryophyllene and eugenol in clove extract, and curcuminoids in turmeric extract are three all-natural, high-quality ingredients. The growing of the plants themselves provides the conditions for these herbs to produce the right quantities of medicinal molecules, and then the processing ensures that the content of these medicinal molecules is precisely defined and always the same (i.e. standardised). These are not just ordinary extracts, but the result of scientific research into the healing power of nature.

Triple action.

Palmitoylethanolamides and BCP affect PPAR receptors, which regulate fat and sugar metabolism, and reduce inflammation and pain.

Palmitoylethanolamide and beta-caryophyllene increase the activity of CB2 endocannabinoid receptors, thus reducing inflammation and pain also through this channel.

Curcuminoids and eugenol regulate dendritic immune cells and the ratio of immune T cells that tolerate inflammation. They act by reducing inflammation by stopping the immune system's signals to continue to cause inflammation throughout the body.

Four patented, clinically tested extracts.

Palmitoylethanolamide has been investigated by scientists in more than 350 studies, and our formulation is the subject of 8 different clinical studies (on Covid relief and long Covid[1], on pain reduction[2], on knee arthritis support[3], on faster recovery after sport[4], on reducing pain during the menstrual cycle[5], etc.).

Beta caryophyne is the subject of a clinical study on pain reduction comparable to analgesics such as ibuprofen and paracetamol.[6]

Eugenol is a powerful antioxidant that scavenges free radicals in cells. It reduces most markers of inflammation through the NF- channelκB.[7]

Curcumin C3 complex is one of the most clinically tested turmeric extracts in the world with over 50 studies.[8]

[1] FONNESU, R., Palmitoylethanolamide (PEA) Inhibits SARS-CoV-2 Entry by Interacting with S Protein and ACE-2 Receptor, Viruses, Vol. 14 (2022), pp. 1080-1898.

[2] BRISKEY, D., EBELT, P., STEELS, E., SUBAH, S., BOGODA, N., RAO., A., Efficacy of Palmitoylethanolamide (Levagen+TM) Compared to Ibuprofen for Reducing Headache Pain Severity and Duration in Healthy Adults: A Double-Blind, Parallel, Randomized Clinical Trial, 690 Food and Nutrition Sciences, Vol. 13 (2022), pp. 690-701.

[3] BRISKEY, D., ROCHE, G., RAO, A., The Effect of a Dispersible Palmitoylethanolamide (Levagen+) Compared to a Placebo for Reducing Joint Pain in an Adult Population - A Randomised, Double-Blind Study, International Journal of Nutrition and Food Sciences, Vol. 10, No. 1 (2021), pp. 9-13.

[4] MALLARD, A., BRISKEY, D.,RICHARDS, A., MILLS, D., RAO, A., The effect of orally dosed Levagen+ (palmitoylethanolamide) on exercise recovery in healthy males - a double blind, randomized, placebo-controlled study, Nutrients, Vol. 12, No. 3 (2020), p. 596.

[5] RAO, A., ERICKSON, J., BRISKEY, D., Palmitoylethanolamide (Levagen+) for acute menstrual pain: a randomized, crossover, doubleblind, placebo-controlled trial, Women & Health, Vol. 65, No. 3 (2025), pp. 237-245.

[6] BIOSFERED, PipeNig®, a black pepper (Piper nigrum) extract with standardized content of (E)-β-caryophyllene, A natural source of an endo-cannabinoid CB2 receptor agonist, Nutrafoods, Vol. 17 (2018), pp. N12-N23.

[7] BARBOZA, J. N., DA SILVA MAIA BEZERRA FILHO, C., SILVA, R.O., MEDEIROS, J.V.R., DE SOUSA, D.P., An Overview on the Anti-inflammatory Potential and Antioxidant Profile of Eugenol, Oxidative Medicine and Cellular Longevity, Vol. 2018, pp. 3957262.

[8] SABINSA, Curcumin C3 Commplex, available at: https://sabinsa.eu/products-from-sabinsa/127-curcumin-c3-complex.