15,33 €
Dietary supplement with three categories of ingredients:
for optimal iron intake.
221 – ACTIVECARE capsules:
Packaged in vegan/cellulose capsules (HPMC):
Packaged in blister packs:
Developed and manufactured in Slovenia in production facilities with GMP, IFS, ISO9001, and BIO certifications.
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Ascorbic acid, bulking agent: modified corn starch, iron (AB-Fortis®), anti-caking agents: magnesium stearate, talc, and silicon dioxide, methylcobalamin, folic acid, vegan capsule: hydroxypropyl methylcellulose (HPMC).
AB-Fortis® is a trademark of Frutarom.
Net quantity:
8.2 g (30 capsules x 275 mg)
The recommended daily intake should not be exceeded.
Food supplements are not a substitute for a balanced and varied diet and a healthy lifestyle.
Store out of reach of children, in a dry place at room temperature in the original packaging.
Take 1 capsule once a day one hour before a meal with 150 ml of water or our tea.
Iron is an important mineral for the human body, as it participates in the transport of oxygen with hemoglobin throughout the body. However, iron intake is often too low in certain populations.
Risk groups for iron and vitamin B deficiency9 and B12
Risk groups for iron and vitamin B deficiency9 and B12 are pregnant women and nursing mothers, athletes, vegans and vegetarians, and the elderly.
Pregnant women and nursing mothers
Women of reproductive age need twice as much iron as men of similar age, but the average Western diet does not meet the nutritional needs of pregnant women.
Vegans and vegetarians
Iron levels in vegans and vegetarians are at risk due to:
- absence of highly bioavailable heme iron in a meat-free diet,
- low bioavailability of non-heme iron in plant foods.
Not all vegans and vegetarians are at risk, but they do belong to a risk group. Fatigue can be a sign of iron deficiency.
Common dietary sources of vitamin B12 are foods of animal origin: meat, milk, eggs, fish, and shellfish. Therefore, a deficiency of vitamin B12 often in people who have been following a long-term vegan diet that does not include these foods. With such a strict diet, it is necessary to monitor vitamin B intake or status.12 and add it as needed.
Athletes
Exercise increases the demand for oxygen in the muscles, which increases hemoglobin production and thus the need for iron.
Sweating can cause a loss of up to 2.5 micrograms of iron per liter of sweat.
Inflammation caused by exercise increases levels of hepcidin, a protein that regulates iron and blocks its absorption in the intestines.
Older adults
After the age of 50, the prevalence of anemia in adults increases and exceeds 20% in those older than 85. In nursing homes, anemia is present in 48% to 63% of residents. Men are more at risk.
Problems with standard iron supplements
Although heme iron is best absorbed, dietary supplements containing heme iron are dangerous because they are easy to overdose on. Furthermore, they are not suitable for vegans and vegetarians.
Non-heme iron from food is biologically poorly available.
Non-heme iron supplements are in the form of Fe2+. The latter has good bioavailability, but is difficult to use in practice, as patients often voluntarily discontinue treatment due to excessive side effects. Side effects are due to the fact that an excessive amount of iron is usually added for sufficient absorption, and the unabsorbed Fe residue2+ iron passes into the intestines. Fe2+ The free atom form is highly reactive, causing oxidative stress and binding to other molecules.
Many iron supplements also have other drawbacks, such as Rapid oxidation in the capsule itself and a short shelf life due to poor stability.
Advantages of 221 - ACTIVECare iron supplements
AB Fortis iron is microencapsulated, i.e. wrapped in alginate, which survives stomach acid. Since iron is in the form of Fe3+ , alginate helps prevent stomach acid from converting it into a form that is unusable by the body. Alginate dissolves in the more alkaline environment of the duodenum, thus Fe3+ atoms come into direct contact with the cells of the intestinal mucosa. There, the enzyme duodenal cytochrome b (Dcyt b) causes reduction with Fe3+ in Fe2+.
This prevents iron overdose and allows the body to absorb the amount it needs. Excess iron from the supplement passes through the rest of the digestive tract in a less reactive form, which causes fewer or no side effects.
Excellent bioavailability
In vivo A study has shown that AB Fortis® is not only easily absorbed, but also significantly incorporated into hemoglobin. In vivo A study does not necessarily mean that the same thing will happen in humans. Therefore, a clinical study was conducted to measure iron markers in the blood (i.e., the end result). The clinical study showed that the bioavailability of AB Fortis iron is at least as good as that of ferrous sulfate. Ferrous sulfate is the standard for good bioavailability.
Exceptional stability
Excellent long-term stability of AB Fortis iron, as less than 1 % iron loss occurs in an aqueous medium at 25 °C over 12 months. It is also resistant to high pressure (less than 2 % iron loss at 1,000 bar) and high temperatures (less than 0.5 % iron loss at 125°C in 3 hours). This gives it unmatched stability during the production process itself and also in the final product on the shelf.
Added vitamin C increases the absorption of non-heme iron from food*
Added vitamin B9 (folic acid), vitamin B12, and iron contribute to normal hemoglobin and red blood cell formation.
Iron absorbed in the duodenum must then bind to hemoglobin. Hemoglobin must then integrate into red blood cells, which transport oxygen through the blood to organs such as muscles. Vitamins B9 and B12 contribute to the normal formation of hemoglobin and red blood cells.
Added vitamin B9 (folic acid) also contributes to increased folate levels.
Folate is extremely important for pregnant or breastfeeding mothers, as it contributes to the normal development of infants.***
Iron also contributes to normal cognitive development in children and normal cognitive function in adults.****
Iron contributes to normal oxygen transport in the body, and together with vitamin C, they contribute to reducing fatigue.*****
Iron contributes to the normal functioning of the immune system******
* Health claim authorized by the European Food Safety Authority (EFSA), ID132
** Health claim authorized by the European Food Safety Authority (EFSA), ID92, ID249
Health claim authorized by the European Food Safety Authority (EFSA), ID253
Health claim authorized by the European Food Safety Authority (EFSA), ID139, ID250
****** Health claim authorized by the European Food Safety Authority (EFSA), ID252
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221 ActiveCare capsules are a supplement combining AB-Fortis® iron, vitamin C, vitamin B9 (folic acid), and vitamin B12 to support iron absorption, increase energy, and healthy haemoglobin and blood cell formation. It helps reduce fatigue and promotes overall vitality.
221 ActiveCare capsules use microencapsulated AB-Fortis® iron to enhance absorption with less or no digestive discomfort compared to standard iron supplements. It boosts haemoglobin and oxygen levels, making it ideal complete combination for those with iron deficiency.
Vitamin C in 221 ActiveCare capsules enhances iron absorption, supports immune health, and reduces fatigue. It helps improve energy levels and acts as antioxidant.
Yes, 221 ActiveCare capsules are suitable for vegans and vegetarians. They provide iron and vitamin B12, supporting energy levels and reducing fatigue, especially in those with restricted diets.
Take one capsule daily with water, one hour before a meal. The microencapsulated iron ensures effective absorption with minimal side effects, boosting energy and supporting red blood cell production.
[1] EMS, T., ST LUCIA, K., HUECKER, M. R., Biochemistry: Iron Absorption, StatPearls, Treasure Island (2022). Iron Absorption and Its Role in Human Metabolism
[2] LEE, A. I., OKAM, M. M., Anemia in Pregnancy, Hematology/Oncology Clinics of North America, Vol. 25, Issue 2 (2011), pp. 241–259. Anemia in Pregnancy: The Role of Iron, Folate, and Vitamin B12 Deficiencies
[3] HAIDER, L. M., SCHWINGSHACKL, L., HOFFMANN, G., EKMEKCIOGLU, C., The Effect of Vegetarian Diets on Iron Status in Adults: A Systematic Review and Meta-Analysis, Critical Reviews in Food Science and Nutrition, Vol. 58, Issue 8 (2018), pp. 1359–1374. Iron and Ferritin Levels in Vegetarian and Vegan Adults
[4] WATANABE, F., Vitamin B12 Sources and Bioavailability, Experimental Biology and Medicine, Vol. 232, Issue 10 (2007), pp. 1266–1274. Vitamin B12 Sources and Bioavailability in Human Nutrition
[5] DAHLQUIST, D. T., STELLINGWERFF, T., DIETER, B. P., Effects of Macro- and Micronutrients on Exercise-Induced Hepcidin Response in Highly Trained Endurance Athletes, Applied Physiology, Nutrition and Metabolism, Vol. 42 (2017), pp. 1036–1043. Nutrient Effects on Hepcidin and Inflammation After Intense Exercise.
[6] SALIVE, M. E., CORNONI-HUNTLEY, J., GURALNIK, J. M., PHILLIPS, C. L., WALLACE, R. B., OSTFELD, A. M., et al., Anemia and Hemoglobin Levels in Older Persons: Relationship with Age, Gender, and Health Status, Journal of the American Geriatrics Society, Vol. 40 (1992), pp. 489–496. Age-Related Changes in Hemoglobin and Anemia in Older Adults
[7] HYDER, S. M., PERSSON, L. A., CHOWDHURY, A. M., EKSTRÖM, E. C., Do Side-Effects Reduce Compliance to Iron Supplementation? A Study of Daily- and Weekly-Dose Regimens in Pregnancy, Journal of Health, Population and Nutrition, Vol. 20, Issue 2 (2002), pp. 175–179. Compliance with Daily vs. Weekly Iron Supplementation in Pregnancy
[8] EKMEKCIOGLU, C., FEYERTAG, J., MARKTL, W., A Ferric Reductase Activity Is Found in Brush Border Membrane Vesicles Isolated from Caco-2 Cells, Journal of Nutrition, Vol. 126, Issue 9 (1996), pp. 2209–2217. Ferric Reductase Activity in Enterocyte Brush Border Membranes
[9] LÁZARO, E., SANTAS, J., RAFECAS, M., Recovery from Dietary Iron Deficiency Anaemia in Rats by the Intake of Microencapsulated Ferric Saccharate, Journal of Food Science and Technology, Vol. 54, Issue 9 (2017), pp. 2913–2918. Microencapsulated Ferric Saccharate for Improving Iron Deficiency Anemia.
[10] CONTRERAS, C., BARNUEVO, M. D., GUILLEN, I., LUQUE, A., LÁZARO, E., ESPADALER, J., LÓPEZ-ROMÁN, J., VILLEGAS, J. A., Comparative Study of the Oral Absorption of Microencapsulated Ferric Saccharate and Ferrous Sulfate in Humans, European Journal of Nutrition, Vol. 53 (2014), pp. 567–574. Postprandial Iron Response to Microencapsulated Ferric Saccharate
